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KMID : 0388220080150030197
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Journal of the Korean Rheumatism Association
2008 Volume.15 No. 3 p.197 ~ p.203
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Glucosamine Sulfate and Chondroitin Sulfate for the Treatment of Osteoarthritis
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Lee Young-Ho
Ji Jong-Dae
Song Gwan-Gyu
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Abstract
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Osteoarthritis (OA) is the most common form of arthritis often associated with morbidity, disability, functional impairment and impaired quality of life. A new perspective in OA management is to delay disease progression by modifying joint structure. Glucosamine sulfate (GS) and chondroitin sulfate (CS) have attracted a lot of interest as a specific drug for OA. Glucosamine is a constituent of glcosaminoglycans in cartilage matrix and synovial fluid and is involved in cartilage formation. Chondroitin sulfate (CS) belongs to the glycosaminoglycan group and is a major component of the articular cartilage. The meta-analyses have shown that GS (but not glucosamine hydrochloride) and CS have small-to-moderate symptomatic efficacy in OA. With respect to the structure-modifying effect, there is some evidence that GS and CS may interfere with structural progression of OA.
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KEYWORD
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Glucosamine, Chondroitin, Osteoarthritis
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